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| Post date: 2024/01/14 |
A scaffold was developed for tissue engineering applications.
Researchers at the School of Biomedical Engineering, AmirKabir University of Technology, have succeeded in designing a conductive scaffold for ion exchange for tissue engineering applications.
According to the public relations office of AmirKabir University of Technology, Zahra Darai Nejad, a graduate of AmirKabir University of Technology and the executor of the project "Design and Fabrication of a Conductive Scaffold Based on Polyaniline/Ion Exchange Polymer for Tissue Engineering Applications," said: "One of the new approaches in tissue engineering is the transmission of electrical signals to cells and the regulation of cellular behaviors.
She stated that the transmission of electrical signals to cells occurs through conductive substrates, adding that conductive scaffolds based on polyaniline generally suffer from conductivity instability and some toxicity, which create difficulties for cellular studies.
The researcher continued: "As a result, in this project, a scaffold with excellent biocompatibility and special conductivity properties was designed to provide a suitable platform for the transmission of electrical signals to cells.
She added: "In this project, by employing an ion exchange polymer as a carrier in the fabrication of conductive nanofibers of polyaniline and using lithium ions, we prepared a biocompatible scaffold with stable conductivity and energy storage capability.
Darai Nejad added: "This scaffold maintains its conductivity in cell culture for a long period of time, it does not have toxicity due to dopant, and with the release of lithium ions, it improves cellular behaviors such as proliferation and differentiation.
The graduate of AmirKabir University of Technology further stated: "The results of this project showed that the simultaneous use of a conductive scaffold, electrical signals, and lithium ions can induce bone formation in the body.
She also mentioned: "The conductive scaffold prepared in this project, in addition to all the subfields of biomedical engineering such as tissue engineering, drug release, biosensors, and wound dressings, also has applications in chemical and electronic industries such as battery manufacturing.
She stated that this scaffold can be used as an electrical stimulator and as a means of releasing biological ion factors, adding: "Based on the studies published in reputable scientific journals, the intended system is novel.
The researcher added: "We intend to continue this research by working on the fabrication of conductive scaffolds with similar performance to batteries for stimulating body tissues, without the need for an external stimulation source.
Referring to the features of the project, she said: "In this project, a conductive ion exchange scaffold for use in tissue engineering was prepared. The biocompatibility of the scaffold was evaluated in both extracorporeal and intracorporeal environments, and it showed very good biocompatibility compared to control samples.
This researcher continued: "Furthermore, the capability of this scaffold for the differentiation of bone marrow-derived stem cells in an extracorporeal environment and induction of bone formation in rats was investigated, and very promising results were obtained.
Referring to other features of the project, she said: "Moreover, the effect of external electrical signals on the growth, proliferation, differentiation of stem cells, and induction of bone formation in rats was studied. The results showed that the conductive scaffold containing lithium ions, along with the induction of electrical signals, had a very effective role in the growth, proliferation, differentiation of cells, and induction of bone formation in rats.
She mentioned the competitive advantages of the project: "The ion exchange conductive scaffold, in addition to tissue engineering and biomedical engineering in general, has applications in other industries such as electronics and chemistry.
Darai Nejad stated: "This research has extensive applications in various fields of biomedical engineering. One of its most significant applications is in tissue engineering. In fact, the biologically active conductive scaffold based on polyaniline is used for transmitting electrical signals to cells and regulating cellular behaviors.
She added that this scaffold can also be used for the transfer of other ions for engineering heart, nerve, and muscle tissues, and due to its special conductivity properties, it can also be used for battery and electronic equipment manufacturing.
It is worth mentioning that the advisor of this project was Dr. Iman Shabanian, a faculty member at AmirKabir University of Technology.
Researchers at the School of Biomedical Engineering, AmirKabir University of Technology, have succeeded in designing a conductive scaffold for ion exchange for tissue engineering applications.
According to the public relations office of AmirKabir University of Technology, Zahra Darai Nejad, a graduate of AmirKabir University of Technology and the executor of the project "Design and Fabrication of a Conductive Scaffold Based on Polyaniline/Ion Exchange Polymer for Tissue Engineering Applications," said: "One of the new approaches in tissue engineering is the transmission of electrical signals to cells and the regulation of cellular behaviors.
She stated that the transmission of electrical signals to cells occurs through conductive substrates, adding that conductive scaffolds based on polyaniline generally suffer from conductivity instability and some toxicity, which create difficulties for cellular studies.
The researcher continued: "As a result, in this project, a scaffold with excellent biocompatibility and special conductivity properties was designed to provide a suitable platform for the transmission of electrical signals to cells.
She added: "In this project, by employing an ion exchange polymer as a carrier in the fabrication of conductive nanofibers of polyaniline and using lithium ions, we prepared a biocompatible scaffold with stable conductivity and energy storage capability.
Darai Nejad added: "This scaffold maintains its conductivity in cell culture for a long period of time, it does not have toxicity due to dopant, and with the release of lithium ions, it improves cellular behaviors such as proliferation and differentiation.
The graduate of AmirKabir University of Technology further stated: "The results of this project showed that the simultaneous use of a conductive scaffold, electrical signals, and lithium ions can induce bone formation in the body.
She also mentioned: "The conductive scaffold prepared in this project, in addition to all the subfields of biomedical engineering such as tissue engineering, drug release, biosensors, and wound dressings, also has applications in chemical and electronic industries such as battery manufacturing.
She stated that this scaffold can be used as an electrical stimulator and as a means of releasing biological ion factors, adding: "Based on the studies published in reputable scientific journals, the intended system is novel.
The researcher added: "We intend to continue this research by working on the fabrication of conductive scaffolds with similar performance to batteries for stimulating body tissues, without the need for an external stimulation source.
Referring to the features of the project, she said: "In this project, a conductive ion exchange scaffold for use in tissue engineering was prepared. The biocompatibility of the scaffold was evaluated in both extracorporeal and intracorporeal environments, and it showed very good biocompatibility compared to control samples.
This researcher continued: "Furthermore, the capability of this scaffold for the differentiation of bone marrow-derived stem cells in an extracorporeal environment and induction of bone formation in rats was investigated, and very promising results were obtained.
Referring to other features of the project, she said: "Moreover, the effect of external electrical signals on the growth, proliferation, differentiation of stem cells, and induction of bone formation in rats was studied. The results showed that the conductive scaffold containing lithium ions, along with the induction of electrical signals, had a very effective role in the growth, proliferation, differentiation of cells, and induction of bone formation in rats.
She mentioned the competitive advantages of the project: "The ion exchange conductive scaffold, in addition to tissue engineering and biomedical engineering in general, has applications in other industries such as electronics and chemistry.
Darai Nejad stated: "This research has extensive applications in various fields of biomedical engineering. One of its most significant applications is in tissue engineering. In fact, the biologically active conductive scaffold based on polyaniline is used for transmitting electrical signals to cells and regulating cellular behaviors.
She added that this scaffold can also be used for the transfer of other ions for engineering heart, nerve, and muscle tissues, and due to its special conductivity properties, it can also be used for battery and electronic equipment manufacturing.
It is worth mentioning that the advisor of this project was Dr. Iman Shabanian, a faculty member at AmirKabir University of Technology.